Saturday night's Len Hall Tribute Match between Fremantle and North Melbourne will go ahead without a crowd after WA was sent into a three-day lockdown.
WA premier Mark McGowan announced a snap lockdown on Friday afternoon in response to community transmission of COVID-19.
The Perth and Peel regions will enter the lockdown at midnight Friday, but it was confirmed the round six match at Optus Stadium would be allowed to go ahead under strict conditions.
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Only essential staff and players will be permitted to attend the game which will be broadcast live via Foxtel and Kayo, and via the Seven Network in Perth.
AFL Executive General Manager Football Operations Steve Hocking said the health and safety of everyone remains paramount and the league would continue to take the advice of governments and health officials.
“The health and safety of everyone in the game and the wider community remains the priority as we continue to navigate the pandemic,” Mr Hocking said.
“The AFL thanks all supporters for their understanding as we continue to be led by the advice of governments and health officials.”
Optus Stadium had recently opened to 100 per cent capacity and last week attracted the largest AFL crowd since COVID-19 hit, with 54,159 fans attending the Friday night clash between West Coast and Collingwood.
The Eagles have already travelled to Geelong on a charter flight ahead of their clash with the Cats at GMHBA Stadium on Saturday.
McGowan was hopeful the lockdown, which is due to end at midnight on Monday, would not need to be extended.
The club will be providing additional information directly to members who had purchased tickets to attend the match.