Carlton will be without three key players for Sunday afternoon's clash with North Melbourne at Marvel Stadium.

Defenders Kade Simpson and Nic Newman, and ruckman Matthew Kreuzer have been ruled out with their respective injuries.

“‘Simmo’ [Kade Simpson] had some hamstring tightness during the game,” Carlton's director of high performance Andrew Russell told the club's website. 

“He has got some low-grade damage in his hamstring and we expect him to miss the next three weeks.

“Nic Newman had some knee soreness, he’s got some low-level damage to his patella tendon.

“These can be quite challenging to manage and at this stage we probably expect him (Newman) to miss around the next three weeks.

“Matty Kreuzer got a cork to his hamstring in the game, which caused him to change his running mechanics.

“He’s actually got a bit of muscle overload to his adductor region and inside hamstring. It will probably see him miss a week."

Key-forward Charlie Curnow could be in the mix to return from a knee injury.