Nick Larkey, Luke McDonald and Tarryn Thomas will all return to the North Melbourne team for Round 6.
Larkey will play his first game at AFL level since late 2017, with the versatile tall set to provide another focal point in attack for the Roos.
The number 20 has proven his goal-kicking credentials in recent years, taking out the Frosty Miller Medal in the VFL in 2018.
McDonald will return after serving his one-week ban for rough conduct, as will Tarryn Thomas, who was rested on Good Friday.
Jy Simpkin, Paul Ahern and Bailey Scott have been omitted.
See the full team below, presented by The Wharf Hotel.