North Melbourne's tough season has gone from bad to worse, with a litany of injuries topping off a 70-point loss to Port Adelaide on Saturday.

Star midfielder Luke Davies-Uniacke (29 disposals, eight clearances) was a shining light in the defeat, but is "very unlikely" to feature next week after suffering a hamstring injury.

"We've got four or five guys that are very sore out of the game," North coach Alastair Clarkson said post-match.

Darcy Tucker (hamstring), Flynn Perez (concussion) and Jack Mahony (shoulder) could all join Davies-Uniacke on the sidelines. 

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While Todd Goldstein (55 hitouts, 24 disposals and 11 clearances) and Nick Larkey (four goals) fought valiantly, North was sloppy when delivering the ball inside 50 and offered little resistance the other way, with Port Adelaide frequently taking the ball from end-to-end with ease.

"The gap between us and Port Adelaide was stark, in terms of our ball use," Clarkson admitted.