Not so long ago Melbourne were the easybeats of the League, but now it's North Melbourne's turn to go through some growing pains.

That's a key point for Kangaroos coach Alastair Clarkson as his side deals with the brutal realities of rebuilding.

The Demons overwhelmed the Kangaroos by 90 points on Saturday night, but Clarkson notes that not long before Melbourne won the 2021 premiership, it was right where North Melbourne is now.

"I reckon they have, if not eight, maybe as many as 10 blokes who are All-Australian quality," Clarkson said.

"What we saw is the gap between one of the better sides in the competition and one of the not-so good sides.

"They've been in the same position as what we are right now ... the dangling carrot for us is because we know what their path has been, there's hope and prospect for us as a footy club as well."

Injuries are hitting North hard and Clarkson said their core 10 players collectively had been sidelined for probably half their games so far this season.

"It's tough yards, but we'll roll up the sleeves, get to work," Clarkson said.

"They're a highly credentialed side and I'd be very surprised if they're not top four and challenging seriously for the flag."

DEMONS v KANGAROOS Full match coverage and stats

Clarkson added that, overall, they played better than in their previous two losses, but Melbourne were just too talented for them.

"It didn't help us much in terms of scoreboard difference, but it helps in giving us some relief that we can control the ball for longer periods," he said.