The Kangaroos will head to the Apple Isle this weekend to host the in-form Demons at Blundstone Arena with Alastair Clarkson back at the helm.
North Melbourne came agonisingly close to putting an end to its 16-game losing streak in Round 20 but couldn't overcome the Eagles on their home deck, while Melbourne managed to claim a runaway 32-point victory over Richmond on Sunday.
Here's everything you need to know for the match in this week's gameday guide.
Set your matchday reminders
Sunday, August 6
North Melbourne v Melbourne at Blundstone Arena, 1.10pm AEST
The Roos will be out for revenge when they face off with a Demons outfit that was a class above back when the two sides met in Round 7 at the MCG.
Conquering Simon Goodwin's group will be a challenging task though, as it looks to claim a fifth straight win with finals football approaching.
So you don't miss the game, or any others this season, make sure to sync the fixture to your calendar.
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Tickets are still available for the Round 21 clash with the Demons.
Getting to Blundstone Arena
Transport information getting to and from the ground can be found here.
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Sunday's game will be broadcast live on Foxtel and Kayo Sports.
Stay connected on social media
For behind-the-scenes access and all the best highlights, photos, stats and stories, we’ve got you covered.
Follow the @NMFCOfficial accounts on Twitter, Instagram and Facebook to stay up to date with everything happening at the match and don't forget to use #Kangas.
Bring on the Demons!