Fremantle's Jonathon Griffin is set to miss the clash against North Melbourne.

The ruckman was a late withdrawal from the Dockers' side on Saturday, while his replacement Aaron Sandilands went on to be one of his team's best players leaving coach Ross Lyon with a tough decision.

Griffin and Sandilands have only twice played in the same side, and Lyon admits he's unlikely to pair them together any time soon.

"I think what happens is when you give your spot up, it's hard to get back in, which is good for me but bad for Jon and great for Aaron," Lyon said.

"I'm suggesting it's really difficult to play both. It's a tough, ruthless business but ... we can't delve into how people feel. It's how they act."

Sandilands had 18 possessions and registered 33 hit-outs in the win against the Tigers.

The Dockers will monitor the fitness of Tendai Mzungu (shoulder), Nat Fyfe (ankle) and Matthew Pavlich (hamstring/Achilles tendon) but are hopeful all three will play.