Defender Miller Bergman is expected to miss the next month of action due to a hamstring injury suffered in Saturday's AFL defeat to Essendon.
The third-year Kangaroo has struggled to get any sort of continuity this season, having already missed several games earlier this year due to a fractured jaw suffered in the opening round of the VFL campaign.
"Miller sustained a hamstring injury after landing awkwardly from a marking contest in the third quarter," North Melbourne head of performance Kevin White told NMFC Media.
"Scans have confirmed a moderate hamstring strain which will likely be a four-week return to play estimation."
Co-captain Jy Simpkin has been provided a clearer timeframe for when he can make his comeback to the senior side.
A quad complaint has kept the midfielder off the park for the past two games, with another fortnight in rehab still to come.
"Jy had been dealing with a low-level quad strain across the past fortnight with his main limitations initially felt on acceleration and deceleration," White said.
"Last week this had cleared but he experienced soreness while kicking which will now see him rehab the injury across the next two weeks as a safeguard for the second half of the season."
On a positive note, Kallan Dawson (ankle) and Brayden George (shoulder) are both expected to make their playing returns this weekend.
Dawson hasn't featured for the Roos since going down with an ankle injury during a training session in the lead-up to Round 6's clash with the Cats, while George has had to recover from a dislocated shoulder suffered in the Round 5 VFL match against Greater Western Sydney.
"Kal has now passed through his ankle rehab program … the past two weeks has seen him put in a huge block of footy conditioning work and lower limb gym work which has set him up for return this week," White said.
"Brayden has put in a solid block of strengthening around that injured shoulder and has passed through his markers in gym.
"He will train fully with the group this week and be available for selection."
Young gun Colby McKercher has "turned a corner" with his bone stress injury, which came out of the game in Darwin against the Suns.
While there isn’t an exact return date for the Tasmanian, the club will look to provide a clearer estimation next week leading into the bye.
"The plan is to carefully monitor his pain scores when walking and once this settles to pain-free we will then look to build loads up, first through AlterG treadmill and then transition out onto the training ground," White said.
Jackson Archer and Hugh Greenwood will both face tests later in the week as they hope to shake off ankle and Achilles issues, respectively.
"Jackson had rolled his ankle in a landing mechanism from a contest against Gold Coast," White said.
"He pulled up sore early last week with a view to test during Friday's main training which he couldn’t quite pass through confidently, but the ankle has trended well since then.
"Hugh has been managing chronic Achilles tendinopathy which at times can flare up and limit his output/function.
"Post-Round 9 there was increased soreness in this region which had him train through levels of discomfort which we deemed too significant to clear for play. Like Jackson, he is trending well at this stage."
Griffin Logue continues to progress in his ACL recovery and is starting to merge into more group training sessions.
"He will continue to build his group training exposure during the week and extend his high-loading footy conditioning sessions on the weekends across the next four weeks," White said.