North Melbourne co-captain Jy Simpkin has been ruled out of the club’s Round 1 game against the Giants.

Simpkin suffered his third concussion in under 12 months in Sunday’s AAMI Community Series match against St Kilda.

"Jy's health and well-being is our number one priority," general manager of football Todd Viney said.

"Given Jy's concussion history, our medical team will take a conservative approach to his management and recovery as per the AFL's Concussion Protocols.

"Jy came into the club today, he's doing well and is in good spirits but his official return-to-play timeline is unclear at this point as it depends on his progress."