North Melbourne senior coach Alastair Clarkson said the Lions were simply "too good" after the Kangaroos got out to an early three-goal lead.
The Lions went on to defeat the Kangaroos by 75 points and Clarkson said his main frustration came from the ease of Brisbane's goals.
"So many times it was just one extra handball we tried and would turn it over," he said.
"At different stages we were too attacking through the middle of the ground and those turnovers hurt us.
"Just the ease with which they got the goals, it ended up just breaking your spirit a little bit and at different stages we found it hard to get back into the contest."
KANGAROOS v LIONS Full match coverage and stats
The major injury concern for North centres around co-captain Jy Simpkin, who left the field with a hand injury in the second quarter and did not return.
"He couldn't clench his fist properly, so it doesn’t look good for us, but we'll have to see what transpires when he gets X-rayed and scanned over the early part of the week," Clarkson said.
"Where Brisbane are now is where we want to be and where they were four or five years ago is probably where we are now.
"We know the path we're on. By and large we've been pretty competitive, but we came up against a really good unit today."
