Carlton's prized draftee Liam Stocker will be unveiled in his first match against North Melbourne at Marvel Stadium on Sunday.
Rated by the Blues as the sixth-best player in last year's NAB AFL Draft, Stocker's availability at pick 19 triggered a live trade with Adelaide where both clubs swapped future first-round selections.
Stocker will be one of a minimum four forced changes from the side that lost to Hawthorn, with Charlie Curnow another confirmed starter after getting through Friday's training unscathed.
"It's a great opportunity for him and a great chance for our defenders who I think have been working really well as a unit to give 'Stocks' a go at half back and possibly through the midfield as well," coach Brendon Bolton said.
Matthew Kreuzer (adductor), Mitch McGovern (hamstring), Nic Newman (knee) and Kade Simpson (hamstring) all go out through injury.
Bolton wouldn't be drawn on Kreuzer's replacement, with big men Matthew Lobbe and Andrew Phillips added to the squad of 26 that will be trimmed to 22 at 5pm on Friday.
Will Setterfield, Jarrod Garlett, Tom Williamson and potential debutant Angus Schumacher are also in the mix to play against the Roos.